If you are using Visual Studio on a laptop, especially the smaller ones a.k.a. the Netbook, the keys are way too close to each other and I often end up hitting the F1 button instead of the ESC key.
Here’s a simple tip to disable the F1 key in Visual Studio 2005, 2008 or 2010 to save you from some annoyance.
In Visual Studio, Go to Tools > Options > Environment > Keyboard > Select Help.F1Help and say Remove
Simple tip but extremely useful for Netbook owners like me!